1 Feb The management of primary anal fissures is generally non-operative and includes increased dietary fibre, sitz baths, topical ointments and botulinum toxin . While topical diltiazem is the most predominantly studied and clinically used calcium channel blocker, topical nifedipine has also shown some. As an alternative to glyceryl trinitrate rectal ointment, chronic anal fissure may also be treated with topical diltiazem hydrochloride 2% [unlicensed] or nifedipine % [unlicensed] (available from Special-order manufacturers or specialist importing companies), which have a lower incidence of adverse effects than topical. 14 Dec The aim of this prospective clinical trial study was to assess the effectiveness of nifedipine in healing anal fissure, a calcium channel blocker that reduces sphincter pressure. A single-blind randomized comparative trial was setup to compare traditional treatment with stool softeners and 2% lidocaine cream.
A digital rectal exam, which may be painful, may be needed if a definitive diagnosis of anal fissures cannot be made based on a patient's history.
No laboratory tests are indicated at that time. A preponderance of anal fissures heal on their own, and no treatment is needed.
If treatment is necessary, the ambition is to soften pain and constipation. Maintaining bulky, formed stools is the first-line treatment in medical management of anal fissures and in preventing their reoccurrence.
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- The effect of topical nifedipine in treatment of chronic anal fissure. Golfam F(1), Golfam P, Khalaj A, Sayed Mortaz SS. Author information: (1)Depatment of Surgery, Mostafa Khomeini Hospital, Shahed University of Medical Sciences, Tehran, Iran. [email protected] Chronic anal fissure is the most common cause of anal.
- BACKGROUND: Acute anal fissures generally heal spontaneously with minimal or no intervention. Conversely, chronic anal fissures are traditionally treated with surgery. Therapies such as botulinum toxin, isosorbide dinitrate, and glyceryl tinitrate have shown some benefit, but their side-effect profiles are substantial.
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Chronic anal fissure is the most common cause of anal pain associated with internal anal sphincter hypertonia. Reduction of hypertonocity is a special treatment for fissure healing. For this purpose chronic anal fissures were conventionally treated by anal dilatation or by lateral sphincterotomy.
However, both of these methods may cause a degree of incontinence in some patients. The uptake of medical therapies that create a reversible chemical sphincterotomy has recently become widespread.
The aim of this prospective clinical trial study was to assess the effectiveness of nifedipine in healing anal fissure, a calcium channel blocker that reduces sphincter pressure. Recurrence of symptoms occurred in four of healed patients in the nifedipine group and three patients in the control group in two months. The final result of nifedipine application after 12 months follow up was recurrence in 11 patients
Nifedipine Ointment Anal Fissurehealing rates, but more side effects and headaches among nitroglycerin users.
- Nifedipine and diltiazem are calcium channel blockers. They are usually taken as pills to lower blood pressure. But these medicines can also help heal anal fissures. A gel form of these medicines is best. When used as a gel directly on the anus,these medicines work as well as nitroglycerin cream. 1 The gel form of these. 14 Nov Topical nifedipine and topical nitroglycerin — Topical nifedipine works by reducing the internal anal sphincter pressure. Nifedipine is available in pill form for other indications (eg, to treat high blood pressure) but is best used for fissure treatment when compounded into a topical treatment and applied.
- Diltiazem/Nifedipine ointment is used to help heal anal fissures. The ointment relaxes the smooth muscle around the anus and promotes blood flow which helps heal the fissure (tear). The ointment reduces anal canal pressure, which diminishes pain and spasm. We use a diluted concentration of Diltiazem/ Nifedipine.
- The effect of topical nifedipine in treatment of chronic anal fissure. - PubMed - NCBI
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- 11 Jul Nifedipine (% to % gel) and diltiazem (2% cream) decrease mean anal resting pressure and improve fissure healing. 18,19 Several studies suggest that topical CCBs are as effective as GTN and have fewer side effects. CCBs can cause mild headache in up to 25% of patients A single study. 10 Mar Nifedipine—a medication approved as an oral treatment for blood pressure—can reduce internal anal pressure when used in topical gel form. A small amount of the ointment can be applied by the patient directly onto the affected area, % four times per day.5 Topical nitroglycerin also can be used to treat.
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Anal Fissures: A Real Pain
Nifedipine Ointment Anal Fissure.If the fissures require internal examination, clinicians administer anesthesia.